Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-familial	1.49e-02	2.13e-03	5.25e-15	7.15e-17
BRCA-familial Exclusive	12kDiscoControls_10xGenes	2.35e-04	7.57e-02	2.44e-14	2.21e-11
12kDiscoControls_10xGenes Exclusive	BRCA-familial Exclusive	9.37e-02	5.62e-03	2.50e-12	3.16e-15
BRCA-familial Exclusive	12kDiscoControls_10xGenes Exclusive	1.41e-04	2.14e-01	4.37e-13	5.66e-11
12kDiscoControls_10xGenes Exclusive	Overlap	4.43e-03	5.20e-02	5.91e-04	1.68e-02
BRCA-familial Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	3.85e-10	3.14e-03	1.85e-03	2.81e-05



Evaluating how well 12kDiscoControls_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-familial	0.93	1.11	4.25	2.25	7.09
BRCA-familial Exclusive	12kDiscoControls_10xGenes	0.69	0.02	2.38	1.49	8.45
12kDiscoControls_10xGenes Exclusive	BRCA-familial Exclusive	0.93	0.94	3.77	1.89	6.55
BRCA-familial Exclusive	12kDiscoControls_10xGenes Exclusive	0.69	-0.28	1.51	1.46	8.66
12kDiscoControls_10xGenes Exclusive	Overlap	0.93	1.18	1.69	1.73	1.82
BRCA-familial Exclusive	Overlap	1.00	1.56	2.19	2.14	2.43
Overlap	Exclusives	0.61	-1.82	-3.50	-0.80	5.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-familial	0.01	-1.20	1.97	1.54	19.13
BRCA-familial Exclusive	12kDiscoControls_10xGenes	0.02	0.58	5.47	4.13	11.65
12kDiscoControls_10xGenes Exclusive	BRCA-familial Exclusive	0.01	-1.35	1.88	1.24	21.59
BRCA-familial Exclusive	12kDiscoControls_10xGenes Exclusive	0.02	-0.54	1.43	2.57	12.14
12kDiscoControls_10xGenes Exclusive	Overlap	0.00	0.68	1.01	0.33	0.55
BRCA-familial Exclusive	Overlap	0.10	180.67	598.03	286.67	529.58
Overlap	Exclusives	0.03	2.40	9.33	2.75	17.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_10xGenes Exclusive	167	166	TFDP2
BRCA-familial Exclusive	21	21	
Overlap	2	2