Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 12kDiscoControls_10xGenes Exclusive BRCA-somatic 4.77e-02 3.23e-02 7.44e-08 1.87e-13 BRCA-somatic Exclusive 12kDiscoControls_10xGenes 2.09e-04 2.45e-02 8.09e-20 3.02e-09 12kDiscoControls_10xGenes Exclusive BRCA-somatic Exclusive 3.21e-01 7.35e-02 3.64e-06 9.75e-12 BRCA-somatic Exclusive 12kDiscoControls_10xGenes Exclusive 4.92e-04 4.50e-02 1.51e-18 1.06e-08 12kDiscoControls_10xGenes Exclusive Overlap 4.36e-07 4.36e-07 4.36e-07 4.36e-06 BRCA-somatic Exclusive Overlap 4.36e-07 4.36e-07 4.36e-07 8.71e-06 Overlap Exclusives 1.58e-16 8.66e-14 7.74e-89 3.63e-33 Evaluating how well 12kDiscoControls_10xGenes genes are linked to BRCA-somatic genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 12kDiscoControls_10xGenes Exclusive BRCA-somatic 0.87 -0.99 2.47 1.13 7.78 BRCA-somatic Exclusive 12kDiscoControls_10xGenes 0.68 0.01 2.48 1.92 7.89 12kDiscoControls_10xGenes Exclusive BRCA-somatic Exclusive 0.86 -1.27 2.21 0.90 7.10 BRCA-somatic Exclusive 12kDiscoControls_10xGenes Exclusive 0.67 -0.09 2.02 1.46 7.07 12kDiscoControls_10xGenes Exclusive Overlap 1.00 1.11 2.87 1.24 2.76 BRCA-somatic Exclusive Overlap 0.99 1.10 1.65 1.90 2.97 Overlap Exclusives 0.79 2.83 9.47 2.56 16.71 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 12kDiscoControls_10xGenes Exclusive BRCA-somatic 0.02 -1.72 9.09 2.82 49.63 BRCA-somatic Exclusive 12kDiscoControls_10xGenes 0.02 0.08 3.99 3.82 12.29 12kDiscoControls_10xGenes Exclusive BRCA-somatic Exclusive 0.01 -2.37 3.58 0.48 13.06 BRCA-somatic Exclusive 12kDiscoControls_10xGenes Exclusive 0.02 -0.25 2.81 2.86 10.79 12kDiscoControls_10xGenes Exclusive Overlap 0.05 3.26 23.92 19.60 29.36 BRCA-somatic Exclusive Overlap 0.01 -0.00 21.27 16.47 22.50 Overlap Exclusives 0.05 5.85 28.79 9.29 42.96 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 12kDiscoControls_10xGenes Exclusive 166 165 TFDP2 BRCA-somatic Exclusive 34 34 Overlap 3 3