Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-gwas	8.45e-03	5.40e-01	1.61e-08	4.01e-05
BRCA-gwas Exclusive	12kDiscoControls_10xGenes	5.71e-03	8.37e-02	1.22e-13	6.30e-10
12kDiscoControls_10xGenes Exclusive	BRCA-gwas Exclusive	7.10e-03	5.40e-01	2.78e-08	1.09e-04
BRCA-gwas Exclusive	12kDiscoControls_10xGenes Exclusive	3.91e-03	8.85e-02	3.73e-14	1.22e-09
12kDiscoControls_10xGenes Exclusive	Overlap	7.33e-01	2.97e-01	1.58e-01	2.97e-01
BRCA-gwas Exclusive	Overlap	7.13e-01	4.55e-01	6.73e-01	4.95e-01
Overlap	Exclusives	2.19e-10	7.88e-01	1.93e-36	2.95e-13



Evaluating how well 12kDiscoControls_10xGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-gwas	0.62	-0.51	0.48	1.29	5.67
BRCA-gwas Exclusive	12kDiscoControls_10xGenes	0.67	-1.04	1.09	1.20	7.16
12kDiscoControls_10xGenes Exclusive	BRCA-gwas Exclusive	0.62	-0.53	0.43	1.62	5.25
BRCA-gwas Exclusive	12kDiscoControls_10xGenes Exclusive	0.67	-1.03	1.08	1.32	7.49
12kDiscoControls_10xGenes Exclusive	Overlap	0.86	0.37	0.88	0.60	1.26
BRCA-gwas Exclusive	Overlap	0.75	-0.16	0.73	0.12	0.88
Overlap	Exclusives	0.63	-0.22	0.18	0.11	8.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-gwas	0.02	-2.08	0.65	1.84	8.62
BRCA-gwas Exclusive	12kDiscoControls_10xGenes	0.02	-0.19	3.51	3.19	14.43
12kDiscoControls_10xGenes Exclusive	BRCA-gwas Exclusive	0.02	-2.14	0.59	2.30	9.07
BRCA-gwas Exclusive	12kDiscoControls_10xGenes Exclusive	0.02	-0.11	3.66	3.70	13.27
12kDiscoControls_10xGenes Exclusive	Overlap	0.00	-0.25	0.78	-0.21	-0.02
BRCA-gwas Exclusive	Overlap	0.00	-0.43	0.01	-0.34	-0.10
Overlap	Exclusives	0.03	-0.17	-0.12	0.00	8.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_10xGenes Exclusive	168	167	TFDP2
BRCA-gwas Exclusive	172	172	
Overlap	1	1