Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-familial-noBRCAs	5.44e-10	2.01e-08	6.68e-17	5.42e-18
BRCA-familial-noBRCAs Exclusive	12kDiscoCases_10xGenes	1.44e-03	5.53e-03	6.81e-19	3.57e-09
12kDiscoCases_10xGenes Exclusive	BRCA-familial-noBRCAs Exclusive	4.53e-05	8.89e-05	7.95e-09	3.09e-10
BRCA-familial-noBRCAs Exclusive	12kDiscoCases_10xGenes Exclusive	8.90e-02	3.85e-02	1.54e-21	2.04e-08
12kDiscoCases_10xGenes Exclusive	Overlap	2.02e-07	7.51e-06	9.79e-09	8.78e-11
BRCA-familial-noBRCAs Exclusive	Overlap	1.78e-21	3.59e-14	1.78e-21	4.33e-17
Overlap	Exclusives	6.88e-04	3.08e-03	4.21e-23	7.33e-10



Evaluating how well 12kDiscoCases_10xGenes genes are linked to BRCA-familial-noBRCAs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-familial-noBRCAs	0.96	2.08	6.45	2.58	7.11
BRCA-familial-noBRCAs Exclusive	12kDiscoCases_10xGenes	0.68	2.25	3.97	1.46	7.12
12kDiscoCases_10xGenes Exclusive	BRCA-familial-noBRCAs Exclusive	0.95	2.15	5.74	2.41	4.85
BRCA-familial-noBRCAs Exclusive	12kDiscoCases_10xGenes Exclusive	0.66	1.78	3.17	1.15	7.10
12kDiscoCases_10xGenes Exclusive	Overlap	0.97	2.67	3.66	2.56	4.85
BRCA-familial-noBRCAs Exclusive	Overlap	1.00	3.30	4.62	2.89	4.78
Overlap	Exclusives	0.67	1.20	3.82	1.10	7.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-familial-noBRCAs	0.02	-0.08	11.61	6.01	2.97
BRCA-familial-noBRCAs Exclusive	12kDiscoCases_10xGenes	0.04	11.70	39.92	14.70	44.65
12kDiscoCases_10xGenes Exclusive	BRCA-familial-noBRCAs Exclusive	0.01	1.08	5.04	5.09	9.02
BRCA-familial-noBRCAs Exclusive	12kDiscoCases_10xGenes Exclusive	0.02	2.18	11.25	4.17	16.19
12kDiscoCases_10xGenes Exclusive	Overlap	0.01	-0.37	6.39	2.98	9.54
BRCA-familial-noBRCAs Exclusive	Overlap	0.23	221.27	504.75	281.68	475.97
Overlap	Exclusives	0.04	10.37	18.36	14.10	39.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_10xGenes Exclusive	145	145	
BRCA-familial-noBRCAs Exclusive	12	12	
Overlap	9	9