Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 12kDiscoCases_10xGenes Exclusive BRCA-gwas-noBRCA2 2.08e-03 8.13e-01 1.97e-04 5.33e-05 BRCA-gwas-noBRCA2 Exclusive 12kDiscoCases_10xGenes 3.69e-02 5.56e-01 2.49e-04 3.27e-04 12kDiscoCases_10xGenes Exclusive BRCA-gwas-noBRCA2 Exclusive 2.25e-03 8.76e-01 8.70e-04 2.43e-04 BRCA-gwas-noBRCA2 Exclusive 12kDiscoCases_10xGenes Exclusive 1.66e-02 4.60e-01 4.47e-04 1.24e-03 12kDiscoCases_10xGenes Exclusive Overlap 4.36e-07 4.36e-07 4.36e-07 5.23e-05 BRCA-gwas-noBRCA2 Exclusive Overlap 2.28e-01 1.75e-01 1.73e-02 1.77e-03 Overlap Exclusives 6.99e-03 5.96e-03 2.60e-60 7.62e-12 Evaluating how well 12kDiscoCases_10xGenes genes are linked to BRCA-gwas-noBRCA2 genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 12kDiscoCases_10xGenes Exclusive BRCA-gwas-noBRCA2 0.61 -0.60 0.74 0.88 5.14 BRCA-gwas-noBRCA2 Exclusive 12kDiscoCases_10xGenes 0.60 -0.86 -0.48 0.23 4.37 12kDiscoCases_10xGenes Exclusive BRCA-gwas-noBRCA2 Exclusive 0.60 -0.65 0.55 0.54 4.48 BRCA-gwas-noBRCA2 Exclusive 12kDiscoCases_10xGenes Exclusive 0.59 -0.82 -0.64 0.03 4.01 12kDiscoCases_10xGenes Exclusive Overlap 0.99 1.25 2.50 1.59 2.82 BRCA-gwas-noBRCA2 Exclusive Overlap 0.96 0.11 1.29 0.99 2.80 Overlap Exclusives 0.65 1.58 4.36 1.45 11.10 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 12kDiscoCases_10xGenes Exclusive BRCA-gwas-noBRCA2 0.01 -1.67 0.74 0.67 4.43 BRCA-gwas-noBRCA2 Exclusive 12kDiscoCases_10xGenes 0.02 2.02 10.00 6.32 21.91 12kDiscoCases_10xGenes Exclusive BRCA-gwas-noBRCA2 Exclusive 0.01 -1.78 0.08 0.08 3.02 BRCA-gwas-noBRCA2 Exclusive 12kDiscoCases_10xGenes Exclusive 0.02 1.89 9.39 7.19 20.91 12kDiscoCases_10xGenes Exclusive Overlap 0.01 1.01 17.24 10.18 22.78 BRCA-gwas-noBRCA2 Exclusive Overlap 0.01 0.51 13.26 6.98 59.50 Overlap Exclusives 0.03 6.51 9.98 4.61 17.61 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 12kDiscoCases_10xGenes Exclusive 151 151 BRCA-gwas-noBRCA2 Exclusive 169 169 Overlap 3 3