Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-somatic-noBRCAs	3.77e-02	5.74e-02	3.33e-07	4.11e-13
BRCA-somatic-noBRCAs Exclusive	12kDiscoControls_10xGenes	2.69e-03	1.72e-02	3.94e-20	7.32e-10
12kDiscoControls_10xGenes Exclusive	BRCA-somatic-noBRCAs Exclusive	3.23e-01	2.40e-01	1.18e-05	4.81e-11
BRCA-somatic-noBRCAs Exclusive	12kDiscoControls_10xGenes Exclusive	3.03e-03	1.99e-02	2.62e-18	7.15e-09
12kDiscoControls_10xGenes Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
BRCA-somatic-noBRCAs Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	8.71e-06
Overlap	Exclusives	4.97e-14	1.18e-12	2.53e-84	4.21e-32



Evaluating how well 12kDiscoControls_10xGenes genes are linked to BRCA-somatic-noBRCAs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-somatic-noBRCAs	0.86	-1.22	2.34	1.21	7.75
BRCA-somatic-noBRCAs Exclusive	12kDiscoControls_10xGenes	0.68	0.06	2.33	1.66	7.54
12kDiscoControls_10xGenes Exclusive	BRCA-somatic-noBRCAs Exclusive	0.85	-1.15	1.57	1.13	7.79
BRCA-somatic-noBRCAs Exclusive	12kDiscoControls_10xGenes Exclusive	0.67	0.10	1.87	1.35	7.29
12kDiscoControls_10xGenes Exclusive	Overlap	1.00	0.97	2.96	1.33	2.90
BRCA-somatic-noBRCAs Exclusive	Overlap	0.99	1.14	1.98	1.83	3.26
Overlap	Exclusives	0.79	2.86	8.88	2.67	16.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-somatic-noBRCAs	0.02	-1.91	8.52	1.62	49.16
BRCA-somatic-noBRCAs Exclusive	12kDiscoControls_10xGenes	0.02	-0.29	3.54	3.73	8.84
12kDiscoControls_10xGenes Exclusive	BRCA-somatic-noBRCAs Exclusive	0.01	-2.04	1.95	0.72	19.43
BRCA-somatic-noBRCAs Exclusive	12kDiscoControls_10xGenes Exclusive	0.02	-0.39	2.59	2.70	5.93
12kDiscoControls_10xGenes Exclusive	Overlap	0.05	3.48	26.89	7.65	125.22
BRCA-somatic-noBRCAs Exclusive	Overlap	0.01	0.12	24.15	19.46	17.57
Overlap	Exclusives	0.05	6.05	24.73	9.27	38.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_10xGenes Exclusive	164	163	TFDP2
BRCA-somatic-noBRCAs Exclusive	32	32	
Overlap	3	3