Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	GeneGroup2	6.75e-03	5.53e-01	5.73e-08	5.41e-05
GeneGroup2 Exclusive	12kDiscoControls_10xGenes	3.62e-03	8.62e-02	1.32e-12	1.79e-09
12kDiscoControls_10xGenes Exclusive	GeneGroup2 Exclusive	6.70e-03	5.06e-01	3.42e-08	1.47e-04
GeneGroup2 Exclusive	12kDiscoControls_10xGenes Exclusive	3.07e-03	1.04e-01	5.13e-13	2.96e-09
12kDiscoControls_10xGenes Exclusive	Overlap	6.93e-01	2.97e-01	7.92e-02	3.56e-01
GeneGroup2 Exclusive	Overlap	8.71e-01	3.76e-01	9.31e-01	4.55e-01
Overlap	Exclusives	1.60e-10	7.50e-01	1.42e-42	1.42e-12



Evaluating how well 12kDiscoControls_10xGenes genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	GeneGroup2	0.62	-0.39	0.32	1.08	6.25
GeneGroup2 Exclusive	12kDiscoControls_10xGenes	0.67	-1.14	1.01	1.04	8.37
12kDiscoControls_10xGenes Exclusive	GeneGroup2 Exclusive	0.62	-0.40	0.35	1.41	4.76
GeneGroup2 Exclusive	12kDiscoControls_10xGenes Exclusive	0.67	-1.19	0.83	1.15	7.23
12kDiscoControls_10xGenes Exclusive	Overlap	0.86	0.40	0.89	0.78	1.11
GeneGroup2 Exclusive	Overlap	0.75	-0.19	0.75	-0.13	0.97
Overlap	Exclusives	0.62	-0.27	-0.01	0.30	8.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	GeneGroup2	0.02	-1.88	0.22	1.48	10.35
GeneGroup2 Exclusive	12kDiscoControls_10xGenes	0.02	-0.39	3.18	2.36	13.45
12kDiscoControls_10xGenes Exclusive	GeneGroup2 Exclusive	0.02	-1.98	0.48	2.15	6.35
GeneGroup2 Exclusive	12kDiscoControls_10xGenes Exclusive	0.02	-0.31	3.39	3.71	10.85
12kDiscoControls_10xGenes Exclusive	Overlap	0.00	-0.24	1.03	-0.04	-0.06
GeneGroup2 Exclusive	Overlap	0.00	-0.36	-0.03	-0.36	-0.12
Overlap	Exclusives	0.03	-0.21	-0.59	0.16	6.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_10xGenes Exclusive	166	165	TFDP2
GeneGroup2 Exclusive	171	171	
Overlap	1	1