Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
newEA_wavelet_0_1_130genes Exclusive	adgs_25_genes	5.43e-01	3.86e-01	1.85e-05	3.73e-03
adgs_25_genes Exclusive	newEA_wavelet_0_1_130genes	3.84e-03	1.91e-01	1.95e-05	8.99e-09
newEA_wavelet_0_1_130genes Exclusive	adgs_25_genes Exclusive	7.71e-01	5.47e-01	2.84e-05	3.69e-03
adgs_25_genes Exclusive	newEA_wavelet_0_1_130genes Exclusive	1.00e-03	3.35e-01	2.20e-04	5.39e-09
newEA_wavelet_0_1_130genes Exclusive	Overlap	5.03e-01	7.67e-01	8.57e-01	9.46e-01
adgs_25_genes Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	3.66e-02	4.86e-02	1.36e-12	6.03e-16



Evaluating how well newEA_wavelet_0_1_130genes genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
newEA_wavelet_0_1_130genes Exclusive	adgs_25_genes	0.68	-0.73	0.55	0.61	3.14
adgs_25_genes Exclusive	newEA_wavelet_0_1_130genes	0.68	-0.45	1.34	0.91	7.91
newEA_wavelet_0_1_130genes Exclusive	adgs_25_genes Exclusive	0.69	-0.20	0.62	1.21	2.92
adgs_25_genes Exclusive	newEA_wavelet_0_1_130genes Exclusive	0.67	-0.97	0.65	0.33	7.13
newEA_wavelet_0_1_130genes Exclusive	Overlap	0.56	-1.59	-0.81	-0.54	0.30
adgs_25_genes Exclusive	Overlap	1.00	2.97	2.94	2.90	2.67
Overlap	Exclusives	0.72	1.15	2.88	1.37	9.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
newEA_wavelet_0_1_130genes Exclusive	adgs_25_genes	0.00	-0.68	-0.22	0.60	3.73
adgs_25_genes Exclusive	newEA_wavelet_0_1_130genes	0.02	2.41	3.87	5.97	14.05
newEA_wavelet_0_1_130genes Exclusive	adgs_25_genes Exclusive	0.00	-0.49	-0.36	0.87	0.66
adgs_25_genes Exclusive	newEA_wavelet_0_1_130genes Exclusive	0.01	-0.33	-0.13	1.78	7.50
newEA_wavelet_0_1_130genes Exclusive	Overlap	0.00	-1.11	-0.72	-0.29	-0.27
adgs_25_genes Exclusive	Overlap	0.13	239.24	570.14	500.74	72.16
Overlap	Exclusives	0.04	15.64	32.01	13.42	32.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
newEA_wavelet_0_1_130genes Exclusive	127	127	
adgs_25_genes Exclusive	22	22	
Overlap	3	3