Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_EA1_z3_5_73 Exclusive	adgs_25_genes	1.38e-05	2.04e-06	1.47e-05	1.89e-07
adgs_25_genes Exclusive	mu_EA1_z3_5_73	1.93e-01	5.35e-01	1.39e-01	3.94e-01
mu_EA1_z3_5_73 Exclusive	adgs_25_genes Exclusive	1.33e-04	3.34e-05	6.23e-05	4.31e-06
adgs_25_genes Exclusive	mu_EA1_z3_5_73 Exclusive	3.48e-01	8.56e-01	3.60e-01	4.93e-01
mu_EA1_z3_5_73 Exclusive	Overlap	2.07e-03	1.34e-02	2.76e-03	7.68e-03
adgs_25_genes Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.24e-04	8.70e-05	3.81e-06	3.22e-05



Evaluating how well mu_EA1_z3_5_73 genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_EA1_z3_5_73 Exclusive	adgs_25_genes	0.79	2.43	5.00	2.46	5.46
adgs_25_genes Exclusive	mu_EA1_z3_5_73	0.50	0.75	-0.11	0.79	0.04
mu_EA1_z3_5_73 Exclusive	adgs_25_genes Exclusive	0.78	2.43	5.39	2.38	4.75
adgs_25_genes Exclusive	mu_EA1_z3_5_73 Exclusive	0.48	0.34	-0.49	0.26	-0.71
mu_EA1_z3_5_73 Exclusive	Overlap	0.96	2.44	2.50	2.28	2.40
adgs_25_genes Exclusive	Overlap	1.00	2.68	2.11	2.45	2.31
Overlap	Exclusives	0.62	2.14	4.59	2.66	4.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_EA1_z3_5_73 Exclusive	adgs_25_genes	0.01	6.66	11.25	6.75	7.74
adgs_25_genes Exclusive	mu_EA1_z3_5_73	0.01	25.68	22.18	21.85	21.15
mu_EA1_z3_5_73 Exclusive	adgs_25_genes Exclusive	0.01	5.55	12.82	3.85	9.73
adgs_25_genes Exclusive	mu_EA1_z3_5_73 Exclusive	0.01	6.94	9.32	5.52	6.54
mu_EA1_z3_5_73 Exclusive	Overlap	0.00	7.35	0.63	6.24	2.04
adgs_25_genes Exclusive	Overlap	0.11	365.47	275.73	419.48	175.64
Overlap	Exclusives	0.05	17.37	99.08	48.48	93.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_EA1_z3_5_73 Exclusive	71	70	RFPL2
adgs_25_genes Exclusive	23	23	
Overlap	2	2