Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_EA1_z3_172 Exclusive	adgs_25_genes	6.83e-06	9.93e-08	6.39e-06	3.45e-10
adgs_25_genes Exclusive	mu_EA1_z3_172	8.22e-01	3.48e-01	5.97e-04	3.82e-01
mu_EA1_z3_172 Exclusive	adgs_25_genes Exclusive	5.98e-05	1.57e-06	5.40e-05	1.42e-08
adgs_25_genes Exclusive	mu_EA1_z3_172 Exclusive	7.56e-01	3.11e-01	1.89e-03	6.86e-01
mu_EA1_z3_172 Exclusive	Overlap	9.85e-04	4.43e-03	2.96e-04	2.07e-03
adgs_25_genes Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.13e-02	7.11e-03	1.33e-08	5.31e-03



Evaluating how well mu_EA1_z3_172 genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_EA1_z3_172 Exclusive	adgs_25_genes	0.84	2.85	5.79	3.74	6.11
adgs_25_genes Exclusive	mu_EA1_z3_172	0.52	2.06	1.57	2.44	1.12
mu_EA1_z3_172 Exclusive	adgs_25_genes Exclusive	0.83	2.88	4.51	3.51	6.20
adgs_25_genes Exclusive	mu_EA1_z3_172 Exclusive	0.51	1.77	1.36	2.01	0.50
mu_EA1_z3_172 Exclusive	Overlap	0.99	2.14	2.12	2.33	2.35
adgs_25_genes Exclusive	Overlap	1.00	3.06	2.19	2.51	2.33
Overlap	Exclusives	0.57	2.31	4.06	2.32	3.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_EA1_z3_172 Exclusive	adgs_25_genes	0.01	7.83	14.64	15.51	13.75
adgs_25_genes Exclusive	mu_EA1_z3_172	0.02	10.32	10.53	9.33	9.11
mu_EA1_z3_172 Exclusive	adgs_25_genes Exclusive	0.01	7.67	15.60	9.51	5.83
adgs_25_genes Exclusive	mu_EA1_z3_172 Exclusive	0.01	7.59	3.31	5.03	4.40
mu_EA1_z3_172 Exclusive	Overlap	0.00	6.40	6.45	18.52	6.05
adgs_25_genes Exclusive	Overlap	0.11	599.88	324.78	307.68	514.19
Overlap	Exclusives	0.04	16.73	27.96	24.76	29.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_EA1_z3_172 Exclusive	170	168	RFPL2;PRAMEF11
adgs_25_genes Exclusive	23	23	
Overlap	2	2