Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI	AD	9.99e-01	9.95e-01	8.22e-01	1.15e-01
AD	spliceAI	3.16e-01	6.22e-01	5.46e-01	8.43e-01



Evaluating how well spliceAI genes are linked to AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI	AD	0.61	0.12	0.08	-0.30	1.93
AD	spliceAI	0.51	-0.24	0.24	0.17	0.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI	AD	0.00	-0.25	-0.39	-0.34	0.24
AD	spliceAI	0.00	-0.43	-0.29	-0.41	-0.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI	27	27	
AD	25	25