Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP train	GeneGroup2	2.24e-01	8.47e-03	1.01e-01	1.34e-03
GeneGroup2	ADSP train	6.36e-01	2.07e-01	6.09e-02	1.80e-01



Evaluating how well ADSP train genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP train	GeneGroup2	0.65	0.62	1.86	0.62	2.89
GeneGroup2	ADSP train	0.56	2.11	1.70	1.43	1.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP train	GeneGroup2	0.00	0.19	0.83	0.13	1.02
GeneGroup2	ADSP train	0.00	0.17	0.89	0.35	0.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP train	75	73	AC010326.2;AL132671.2
GeneGroup2	25	25