Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADSP train	GeneGroup2	1.65e-02	2.12e-02	1.35e-02	4.18e-04
GeneGroup2	ADSP train	2.90e-01	1.34e-01	9.64e-02	5.60e-02



Evaluating how well ADSP train genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP train	GeneGroup2	0.70	1.87	3.05	1.28	3.29
GeneGroup2	ADSP train	0.62	2.15	1.79	1.32	2.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADSP train	GeneGroup2	0.00	1.50	1.54	0.89	2.41
GeneGroup2	ADSP train	0.00	1.88	1.40	0.39	1.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADSP train	37	36	AC010326.2
GeneGroup2	25	25