Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD train EA-spliceAI Exclusive	EA-spliceAI	3.64e-04	1.38e-04	2.42e-04	1.61e-06
EA-spliceAI Exclusive	AD train EA-spliceAI	5.84e-01	6.24e-01	3.45e-02	4.40e-01
AD train EA-spliceAI Exclusive	EA-spliceAI Exclusive	5.19e-03	6.49e-04	5.51e-04	2.09e-05
EA-spliceAI Exclusive	AD train EA-spliceAI Exclusive	9.33e-01	5.54e-01	4.34e-02	8.04e-01
AD train EA-spliceAI Exclusive	Overlap	2.44e-04	4.36e-07	2.44e-05	1.52e-05
EA-spliceAI Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.68e-04	3.26e-04	2.65e-13	3.11e-04



Evaluating how well AD train EA-spliceAI genes are linked to EA-spliceAI genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD train EA-spliceAI Exclusive	EA-spliceAI	0.82	2.92	4.72	2.41	5.72
EA-spliceAI Exclusive	AD train EA-spliceAI	0.53	1.78	0.74	1.53	1.47
AD train EA-spliceAI Exclusive	EA-spliceAI Exclusive	0.79	2.17	4.43	2.53	5.11
EA-spliceAI Exclusive	AD train EA-spliceAI Exclusive	0.52	1.27	0.68	1.15	0.58
AD train EA-spliceAI Exclusive	Overlap	0.99	2.21	2.50	3.02	2.79
EA-spliceAI Exclusive	Overlap	1.00	3.02	2.28	2.56	3.10
Overlap	Exclusives	0.61	2.50	4.46	2.92	4.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD train EA-spliceAI Exclusive	EA-spliceAI	0.01	4.90	17.91	5.12	14.56
EA-spliceAI Exclusive	AD train EA-spliceAI	0.01	16.00	4.33	14.03	7.89
AD train EA-spliceAI Exclusive	EA-spliceAI Exclusive	0.01	0.90	13.62	2.02	5.43
EA-spliceAI Exclusive	AD train EA-spliceAI Exclusive	0.01	5.62	2.13	2.23	2.25
AD train EA-spliceAI Exclusive	Overlap	0.01	11.36	22.74	13.47	25.09
EA-spliceAI Exclusive	Overlap	0.09	293.65	133.11	309.67	362.85
Overlap	Exclusives	0.05	33.13	77.23	39.34	93.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD train EA-spliceAI Exclusive	89	88	RFPL2
EA-spliceAI Exclusive	22	22	
Overlap	3	3