Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI 	AD	3.73e-01	2.95e-01	3.41e-01	5.38e-02
AD	spliceAI 	6.94e-01	1.65e-01	3.77e-02	6.00e-02



Evaluating how well spliceAI  genes are linked to AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI 	AD	0.64	0.95	0.93	0.52	2.51
AD	spliceAI 	0.59	1.72	1.41	1.40	2.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI 	AD	0.00	0.90	0.31	0.22	-0.00
AD	spliceAI 	0.00	0.76	0.98	0.42	1.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI 	57	55	AC010326.2;AL132671.2
AD	25	25