Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SpliceAI	AD	3.78e-05	2.58e-05	2.85e-05	1.75e-07
AD	SpliceAI	6.44e-01	1.14e-01	5.29e-02	3.08e-02



Evaluating how well SpliceAI genes are linked to AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SpliceAI	AD	0.81	3.22	5.18	2.79	5.43
AD	SpliceAI	0.60	2.11	1.67	1.64	2.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SpliceAI	AD	0.00	6.48	9.99	0.65	9.95
AD	SpliceAI	0.00	3.37	3.50	2.90	4.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SpliceAI	55	53	AC010326.2;AL132671.2
AD	25	25