Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA-spliceAI Exclusive	GeneGroup2	8.33e-07	1.61e-06	1.02e-07	1.39e-07
GeneGroup2 Exclusive	EA-spliceAI	9.25e-02	4.60e-01	4.77e-02	9.20e-02
EA-spliceAI Exclusive	GeneGroup2 Exclusive	1.63e-04	5.85e-05	7.41e-05	1.06e-04
GeneGroup2 Exclusive	EA-spliceAI Exclusive	3.94e-01	5.62e-01	5.49e-02	2.03e-01
EA-spliceAI Exclusive	Overlap	1.31e-06	6.04e-07	3.84e-07	1.31e-06
GeneGroup2 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	9.14e-09
Overlap	Exclusives	7.93e-05	7.87e-04	1.67e-14	1.39e-05



Evaluating how well EA-spliceAI genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA-spliceAI Exclusive	GeneGroup2	0.82	3.08	4.73	3.40	5.46
GeneGroup2 Exclusive	EA-spliceAI	0.57	1.84	1.48	2.05	2.75
EA-spliceAI Exclusive	GeneGroup2 Exclusive	0.79	3.13	4.46	2.48	4.01
GeneGroup2 Exclusive	EA-spliceAI Exclusive	0.55	1.84	1.20	1.47	1.63
EA-spliceAI Exclusive	Overlap	0.99	2.60	2.85	2.69	3.34
GeneGroup2 Exclusive	Overlap	1.00	2.64	2.98	2.82	3.58
Overlap	Exclusives	0.63	3.64	5.28	3.07	5.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA-spliceAI Exclusive	GeneGroup2	0.02	19.38	34.26	23.70	30.37
GeneGroup2 Exclusive	EA-spliceAI	0.02	13.54	14.90	15.37	10.70
EA-spliceAI Exclusive	GeneGroup2 Exclusive	0.01	12.52	22.18	13.29	5.51
GeneGroup2 Exclusive	EA-spliceAI Exclusive	0.01	3.23	4.93	2.88	5.52
EA-spliceAI Exclusive	Overlap	0.02	30.15	32.71	48.65	31.73
GeneGroup2 Exclusive	Overlap	0.09	212.48	239.52	31.82	76.67
Overlap	Exclusives	0.06	29.30	82.36	42.62	46.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA-spliceAI Exclusive	105	104	RFPL2
GeneGroup2 Exclusive	21	21	
Overlap	4	4