Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_ad_ukb_79_3 Exclusive	adgs_25_genes	5.19e-05	7.96e-05	1.72e-08	2.60e-08
adgs_25_genes Exclusive	mu_ad_ukb_79_3	5.14e-02	3.19e-01	2.80e-02	1.08e-02
mu_ad_ukb_79_3 Exclusive	adgs_25_genes Exclusive	5.21e-04	4.03e-04	4.76e-06	2.93e-06
adgs_25_genes Exclusive	mu_ad_ukb_79_3 Exclusive	1.95e-01	4.04e-01	1.24e-01	3.73e-02
mu_ad_ukb_79_3 Exclusive	Overlap	1.52e-05	4.36e-07	4.36e-07	8.71e-06
adgs_25_genes Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	4.58e-05	5.85e-07	1.09e-12	9.16e-08



Evaluating how well mu_ad_ukb_79_3 genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_ad_ukb_79_3 Exclusive	adgs_25_genes	0.81	2.50	4.34	3.40	5.34
adgs_25_genes Exclusive	mu_ad_ukb_79_3	0.60	2.08	1.96	2.15	3.40
mu_ad_ukb_79_3 Exclusive	adgs_25_genes Exclusive	0.79	2.12	4.31	2.44	4.71
adgs_25_genes Exclusive	mu_ad_ukb_79_3 Exclusive	0.58	2.13	1.63	1.76	2.77
mu_ad_ukb_79_3 Exclusive	Overlap	0.99	2.43	2.70	2.54	2.98
adgs_25_genes Exclusive	Overlap	1.00	2.78	2.27	2.69	3.35
Overlap	Exclusives	0.66	3.98	4.83	2.76	5.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_ad_ukb_79_3 Exclusive	adgs_25_genes	0.01	11.36	26.04	23.08	20.36
adgs_25_genes Exclusive	mu_ad_ukb_79_3	0.02	19.19	11.67	13.71	29.41
mu_ad_ukb_79_3 Exclusive	adgs_25_genes Exclusive	0.01	7.35	20.38	10.76	8.64
adgs_25_genes Exclusive	mu_ad_ukb_79_3 Exclusive	0.01	5.58	4.32	4.27	7.61
mu_ad_ukb_79_3 Exclusive	Overlap	0.01	18.90	58.31	31.15	2.58
adgs_25_genes Exclusive	Overlap	0.09	257.14	170.79	125.09	156.77
Overlap	Exclusives	0.05	62.58	83.77	55.10	78.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_ad_ukb_79_3 Exclusive	76	75	C16orf86
adgs_25_genes Exclusive	22	22	
Overlap	3	3