Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1	AD	3.97e-01	2.62e-01	2.15e-01	9.43e-03
AD	GeneGroup1	6.91e-01	4.75e-01	2.48e-01	3.40e-01



Evaluating how well GeneGroup1 genes are linked to AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	AD	0.68	0.68	1.84	1.00	2.92
AD	GeneGroup1	0.58	1.68	0.86	1.03	1.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	AD	0.00	0.03	1.31	0.29	0.06
AD	GeneGroup1	0.00	0.67	0.20	0.43	0.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1	27	26	P2RX5-TAX1BP3
AD	25	25