Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI	GeneGroup2	4.61e-05	7.09e-05	1.19e-05	4.22e-07
GeneGroup2	spliceAI	5.46e-01	1.37e-01	6.27e-02	5.41e-02



Evaluating how well spliceAI genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI	GeneGroup2	0.81	3.30	5.03	3.16	5.17
GeneGroup2	spliceAI	0.60	1.95	1.61	1.70	2.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI	GeneGroup2	0.00	5.43	8.95	3.24	6.77
GeneGroup2	spliceAI	0.00	4.20	3.13	4.19	2.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI	55	53	AC010326.2;AL132671.2
GeneGroup2	25	25