Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceai	gwas	6.19e-05	2.74e-05	1.71e-05	9.39e-07
gwas	spliceai	5.91e-01	1.17e-01	5.29e-02	3.94e-02



Evaluating how well spliceai genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceai	gwas	0.81	3.40	5.17	2.60	5.26
gwas	spliceai	0.60	1.99	1.76	1.79	2.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceai	gwas	0.00	6.23	10.49	2.21	10.25
gwas	spliceai	0.00	4.79	3.86	2.29	2.91

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceai	55	53	AC010326.2;AL132671.2
gwas	25	25