Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_uniqueHIS_z3 Exclusive	adgs_25_genes	2.23e-01	3.19e-01	7.63e-01	2.98e-02
adgs_25_genes Exclusive	mu_uniqueHIS_z3	5.22e-01	4.35e-01	4.79e-02	5.76e-01
mu_uniqueHIS_z3 Exclusive	adgs_25_genes Exclusive	3.56e-01	2.66e-01	8.70e-01	3.41e-02
adgs_25_genes Exclusive	mu_uniqueHIS_z3 Exclusive	6.03e-01	3.50e-01	1.82e-02	6.36e-01
mu_uniqueHIS_z3 Exclusive	Overlap	7.52e-01	1.98e-02	9.50e-01	1.58e-01
adgs_25_genes Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.67e-02	4.02e-03	1.41e-32	3.15e-03



Evaluating how well mu_uniqueHIS_z3 genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_uniqueHIS_z3 Exclusive	adgs_25_genes	0.66	0.82	1.05	0.46	2.33
adgs_25_genes Exclusive	mu_uniqueHIS_z3	0.54	1.77	1.91	1.83	1.30
mu_uniqueHIS_z3 Exclusive	adgs_25_genes Exclusive	0.65	0.57	1.33	0.36	2.39
adgs_25_genes Exclusive	mu_uniqueHIS_z3 Exclusive	0.53	1.82	1.96	2.19	1.05
mu_uniqueHIS_z3 Exclusive	Overlap	0.90	0.52	-291183362024403.69	0.24	1.49
adgs_25_genes Exclusive	Overlap	1.00	1.42	inf	1.80	1.76
Overlap	Exclusives	0.61	inf	4.97	2.18	3.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_uniqueHIS_z3 Exclusive	adgs_25_genes	0.00	0.26	-0.68	-0.10	1.11
adgs_25_genes Exclusive	mu_uniqueHIS_z3	0.01	1.23	1.49	0.96	0.81
mu_uniqueHIS_z3 Exclusive	adgs_25_genes Exclusive	0.00	-0.02	0.58	-0.14	0.22
adgs_25_genes Exclusive	mu_uniqueHIS_z3 Exclusive	0.00	0.37	0.22	0.96	0.32
mu_uniqueHIS_z3 Exclusive	Overlap	0.00	-0.14	-5731897657387685.00	-0.26	0.53
adgs_25_genes Exclusive	Overlap	0.02	41.92	inf	48.42	23.68
Overlap	Exclusives	0.01	-1885190965510210.50	13.20	6.19	3.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_uniqueHIS_z3 Exclusive	83	82	AC004076.1
adgs_25_genes Exclusive	24	24	
Overlap	1	1