Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
apoe2_z_2_5_149 Exclusive	adgs_25_genes	8.05e-08	1.05e-07	2.20e-07	2.98e-08
adgs_25_genes Exclusive	apoe2_z_2_5_149	4.47e-01	1.26e-01	1.28e-04	3.79e-01
apoe2_z_2_5_149 Exclusive	adgs_25_genes Exclusive	5.23e-08	3.00e-08	3.61e-07	4.82e-09
adgs_25_genes Exclusive	apoe2_z_2_5_149 Exclusive	5.59e-01	1.26e-01	1.36e-03	4.78e-01
apoe2_z_2_5_149 Exclusive	Overlap	3.56e-01	7.72e-01	4.16e-01	9.70e-01
adgs_25_genes Exclusive	Overlap	5.94e-02	1.98e-02	3.96e-02	3.96e-02
Overlap	Exclusives	9.98e-05	4.95e-03	1.20e-01	1.03e-02



Evaluating how well apoe2_z_2_5_149 genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
apoe2_z_2_5_149 Exclusive	adgs_25_genes	0.83	3.23	5.36	3.41	5.71
adgs_25_genes Exclusive	apoe2_z_2_5_149	0.52	1.98	1.93	1.65	1.06
apoe2_z_2_5_149 Exclusive	adgs_25_genes Exclusive	0.84	3.55	5.83	2.93	5.47
adgs_25_genes Exclusive	apoe2_z_2_5_149 Exclusive	0.52	2.05	1.97	1.73	0.79
apoe2_z_2_5_149 Exclusive	Overlap	0.50	1.06	0.30	0.75	-0.04
adgs_25_genes Exclusive	Overlap	0.97	1.59	2.25	1.94	1.66
Overlap	Exclusives	0.56	1.73	2.78	1.46	2.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
apoe2_z_2_5_149 Exclusive	adgs_25_genes	0.02	3.08	43.69	17.50	12.21
adgs_25_genes Exclusive	apoe2_z_2_5_149	0.02	11.33	22.44	8.71	17.43
apoe2_z_2_5_149 Exclusive	adgs_25_genes Exclusive	0.02	22.47	45.42	18.75	12.83
adgs_25_genes Exclusive	apoe2_z_2_5_149 Exclusive	0.02	9.44	24.66	23.52	20.66
apoe2_z_2_5_149 Exclusive	Overlap	0.00	0.38	-0.29	-0.06	-0.17
adgs_25_genes Exclusive	Overlap	0.00	0.27	20.67	0.74	3.88
Overlap	Exclusives	0.01	3.87	7.48	2.06	3.60

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
apoe2_z_2_5_149 Exclusive	148	147	C5orf60
adgs_25_genes Exclusive	24	24	
Overlap	1	1