Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_uniqueHIS_z3_balance	adgs_25_genes	2.61e-02	2.23e-02	1.70e-02	9.10e-05
adgs_25_genes	mu_uniqueHIS_z3_balance	1.92e-01	2.45e-01	4.21e-02	8.30e-02



Evaluating how well mu_uniqueHIS_z3_balance genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_uniqueHIS_z3_balance	adgs_25_genes	0.72	1.57	2.22	1.24	4.42
adgs_25_genes	mu_uniqueHIS_z3_balance	0.58	1.05	1.78	1.89	2.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_uniqueHIS_z3_balance	adgs_25_genes	0.00	1.07	0.92	0.78	2.61
adgs_25_genes	mu_uniqueHIS_z3_balance	0.01	1.22	1.62	2.02	2.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_uniqueHIS_z3_balance	90	88	SSPO;AC004076.1
adgs_25_genes	25	25