Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
apoe4_z_3_99_balance Exclusive	adgs_25_genes	2.50e-01	2.80e-01	2.36e-01	2.57e-03
adgs_25_genes Exclusive	apoe4_z_3_99_balance	1.25e-01	3.30e-01	3.97e-02	1.32e-01
apoe4_z_3_99_balance Exclusive	adgs_25_genes Exclusive	5.46e-01	4.69e-01	2.41e-01	4.93e-03
adgs_25_genes Exclusive	apoe4_z_3_99_balance Exclusive	1.30e-01	4.91e-01	7.06e-02	1.76e-01
apoe4_z_3_99_balance Exclusive	Overlap	6.34e-01	6.93e-01	5.94e-01	8.32e-01
adgs_25_genes Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	9.57e-04	7.67e-03	1.04e-03	1.82e-03



Evaluating how well apoe4_z_3_99_balance genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
apoe4_z_3_99_balance Exclusive	adgs_25_genes	0.65	0.52	0.83	0.38	2.36
adgs_25_genes Exclusive	apoe4_z_3_99_balance	0.53	0.98	0.85	0.90	1.16
apoe4_z_3_99_balance Exclusive	adgs_25_genes Exclusive	0.65	0.25	1.01	0.39	2.61
adgs_25_genes Exclusive	apoe4_z_3_99_balance Exclusive	0.53	0.75	0.49	0.72	1.19
apoe4_z_3_99_balance Exclusive	Overlap	0.65	0.64	0.52	0.59	0.45
adgs_25_genes Exclusive	Overlap	1.00	1.70	1.69	2.18	1.79
Overlap	Exclusives	0.60	2.18	3.04	2.27	4.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
apoe4_z_3_99_balance Exclusive	adgs_25_genes	0.00	0.23	1.12	0.12	0.33
adgs_25_genes Exclusive	apoe4_z_3_99_balance	0.01	2.30	0.49	1.81	1.07
apoe4_z_3_99_balance Exclusive	adgs_25_genes Exclusive	0.00	0.12	1.58	0.02	1.27
adgs_25_genes Exclusive	apoe4_z_3_99_balance Exclusive	0.01	0.64	0.05	0.35	0.30
apoe4_z_3_99_balance Exclusive	Overlap	0.00	-0.14	-0.15	-0.17	-0.11
adgs_25_genes Exclusive	Overlap	0.06	61.13	187.15	155.51	64.34
Overlap	Exclusives	0.02	14.05	18.57	13.78	23.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
apoe4_z_3_99_balance Exclusive	98	98	
adgs_25_genes Exclusive	24	24	
Overlap	1	1