Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Mu-diff_males Exclusive	GWAS_catalog	4.41e-01	6.43e-01	7.08e-01	6.17e-02
GWAS_catalog Exclusive	Mu-diff_males	5.89e-01	7.14e-01	1.10e-01	4.55e-01
Mu-diff_males Exclusive	GWAS_catalog Exclusive	4.11e-01	5.97e-01	6.47e-01	6.59e-02
GWAS_catalog Exclusive	Mu-diff_males Exclusive	6.54e-01	7.86e-01	2.86e-01	4.47e-01
Mu-diff_males Exclusive	Overlap	8.62e-01	8.07e-01	7.30e-01	9.82e-01
GWAS_catalog Exclusive	Overlap	8.56e-01	9.12e-01	8.49e-01	8.69e-01
Overlap	Exclusives	9.23e-06	1.98e-02	3.82e-06	1.59e-05



Evaluating how well Mu-diff_males genes are linked to GWAS_catalog genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Mu-diff_males Exclusive	GWAS_catalog	0.56	-0.42	-0.28	-0.39	1.84
GWAS_catalog Exclusive	Mu-diff_males	0.53	-0.27	-0.42	-0.00	1.08
Mu-diff_males Exclusive	GWAS_catalog Exclusive	0.57	-0.41	-0.15	-0.23	2.03
GWAS_catalog Exclusive	Mu-diff_males Exclusive	0.53	-0.15	-0.40	-0.31	1.10
Mu-diff_males Exclusive	Overlap	0.49	-0.08	0.01	-0.23	-0.08
GWAS_catalog Exclusive	Overlap	0.59	1.06	0.40	0.44	0.75
Overlap	Exclusives	0.60	2.04	3.45	2.00	4.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Mu-diff_males Exclusive	GWAS_catalog	0.00	-0.71	-0.56	-0.77	0.17
GWAS_catalog Exclusive	Mu-diff_males	0.01	0.25	-0.04	0.45	0.82
Mu-diff_males Exclusive	GWAS_catalog Exclusive	0.00	-0.77	-0.47	-0.67	0.27
GWAS_catalog Exclusive	Mu-diff_males Exclusive	0.01	-0.35	-0.61	-0.42	0.02
Mu-diff_males Exclusive	Overlap	0.00	-0.32	-0.24	-0.33	-0.41
GWAS_catalog Exclusive	Overlap	0.01	18.82	53.90	19.61	18.55
Overlap	Exclusives	0.01	2.03	1.91	1.70	3.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Mu-diff_males Exclusive	116	116	
GWAS_catalog Exclusive	70	68	CASC16;GPNMB
Overlap	4	4