Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Combined-PD-mu	GS-Juan	1.75e-02	2.96e-02	1.31e-02	3.05e-04
GS-Juan	Combined-PD-mu	1.24e-01	7.11e-01	2.94e-18	4.52e-01



Evaluating how well Combined-PD-mu genes are linked to GS-Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined-PD-mu	GS-Juan	0.82	1.26	1.70	1.24	3.77
GS-Juan	Combined-PD-mu	0.51	0.74	0.50	0.96	0.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined-PD-mu	GS-Juan	0.01	3.09	5.16	3.22	10.47
GS-Juan	Combined-PD-mu	0.01	1.99	1.06	1.42	1.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Combined-PD-mu	159	158	PXYLP
GS-Juan	12	12