Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
FemalePDmu	GSJuan	5.34e-01	5.91e-01	7.00e-01	2.39e-02
GSJuan	FemalePDmu	3.99e-02	5.96e-01	3.11e-13	4.19e-01



Evaluating how well FemalePDmu genes are linked to GSJuan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FemalePDmu	GSJuan	0.75	0.46	0.66	0.19	3.37
GSJuan	FemalePDmu	0.49	-0.07	-0.59	-0.28	-0.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FemalePDmu	GSJuan	0.00	1.51	1.19	1.20	0.13
GSJuan	FemalePDmu	0.01	0.42	0.75	1.08	0.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
FemalePDmu	116	116	
GSJuan	12	12