Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
FemalePDmu	Singleton	2.11e-01	2.19e-01	3.83e-01	6.24e-05
Singleton	FemalePDmu	5.53e-01	8.86e-01	3.74e-07	9.24e-01



Evaluating how well FemalePDmu genes are linked to Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FemalePDmu	Singleton	0.74	1.43	2.17	1.08	3.60
Singleton	FemalePDmu	0.51	1.50	0.04	0.32	0.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FemalePDmu	Singleton	0.00	1.32	2.90	0.94	0.21
Singleton	FemalePDmu	0.01	1.76	1.45	0.36	0.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
FemalePDmu	116	116	
Singleton	21	21