Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Combined-female	GS-Singleton	2.75e-02	1.92e-02	3.09e-02	1.63e-04
GS-Singleton	Combined-female	3.57e-01	2.79e-01	9.15e-04	3.23e-01



Evaluating how well Combined-female genes are linked to GS-Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined-female	GS-Singleton	0.78	2.67	3.81	2.13	4.37
GS-Singleton	Combined-female	0.56	3.10	1.48	1.42	1.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined-female	GS-Singleton	0.00	4.13	8.55	2.74	3.66
GS-Singleton	Combined-female	0.00	0.27	4.22	0.18	2.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Combined-female	35	35	
GS-Singleton	21	21