Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Total_overlap	GS-Juan	5.09e-02	2.03e-02	5.79e-02	1.85e-04
GS-Juan	Total_overlap	2.88e-01	4.68e-01	1.60e-08	4.42e-01



Evaluating how well Total_overlap genes are linked to GS-Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Total_overlap	GS-Juan	0.83	1.96	2.92	1.73	3.88
GS-Juan	Total_overlap	0.51	0.73	-0.04	0.13	0.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Total_overlap	GS-Juan	0.00	1.46	4.30	1.65	1.29
GS-Juan	Total_overlap	0.00	1.92	0.06	1.35	1.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Total_overlap	71	71	
GS-Juan	12	12