Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Combined-female	GS-Juan	4.32e-03	9.20e-03	1.08e-02	1.89e-05
GS-Juan	Combined-female	1.05e-01	4.42e-02	1.77e-06	4.31e-02



Evaluating how well Combined-female genes are linked to GS-Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined-female	GS-Juan	0.87	3.23	3.21	2.49	4.61
GS-Juan	Combined-female	0.57	2.68	1.53	1.82	1.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined-female	GS-Juan	0.00	5.06	3.78	2.24	8.66
GS-Juan	Combined-female	0.00	0.43	3.37	2.02	2.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Combined-female	35	35	
GS-Juan	12	12