Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Combined-male	GS-Juan	6.16e-01	2.08e-01	5.48e-01	2.41e-03
GS-Juan	Combined-male	8.70e-02	1.11e-01	8.89e-05	6.07e-02



Evaluating how well Combined-male genes are linked to GS-Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined-male	GS-Juan	0.71	0.01	0.88	0.09	2.73
GS-Juan	Combined-male	0.45	-0.90	-1.48	-1.43	-1.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined-male	GS-Juan	0.00	-0.42	0.13	-0.34	0.17
GS-Juan	Combined-male	0.00	0.73	-0.22	-0.22	-0.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Combined-male	42	42	
GS-Juan	12	12