Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
combine_y_y_full Exclusive	ad_gs	5.02e-06	1.57e-05	5.48e-06	4.43e-07
ad_gs Exclusive	combine_y_y_full	5.96e-01	6.50e-01	2.74e-02	7.56e-01
combine_y_y_full Exclusive	ad_gs Exclusive	7.93e-04	5.18e-04	6.36e-04	1.13e-04
ad_gs Exclusive	combine_y_y_full Exclusive	7.95e-01	7.41e-01	7.97e-02	9.92e-01
combine_y_y_full Exclusive	Overlap	8.32e-04	3.21e-05	1.32e-03	7.09e-06
ad_gs Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	9.14e-09
Overlap	Exclusives	4.86e-04	4.27e-04	3.95e-17	4.32e-04



Evaluating how well combine_y_y_full genes are linked to ad_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
combine_y_y_full Exclusive	ad_gs	0.78	2.16	4.13	2.33	4.94
ad_gs Exclusive	combine_y_y_full	0.52	1.62	0.78	1.35	1.02
combine_y_y_full Exclusive	ad_gs Exclusive	0.74	1.67	3.34	2.18	4.08
ad_gs Exclusive	combine_y_y_full Exclusive	0.51	1.41	0.48	1.12	0.27
combine_y_y_full Exclusive	Overlap	0.98	2.35	2.67	2.64	3.44
ad_gs Exclusive	Overlap	1.00	3.35	2.94	2.96	3.66
Overlap	Exclusives	0.57	4.27	4.10	2.61	3.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
combine_y_y_full Exclusive	ad_gs	0.01	9.53	14.39	6.43	7.99
ad_gs Exclusive	combine_y_y_full	0.02	9.23	6.87	11.66	8.39
combine_y_y_full Exclusive	ad_gs Exclusive	0.00	4.52	8.12	6.01	0.62
ad_gs Exclusive	combine_y_y_full Exclusive	0.01	2.86	1.81	3.69	3.21
combine_y_y_full Exclusive	Overlap	0.01	8.67	27.56	10.68	26.74
ad_gs Exclusive	Overlap	0.09	163.90	216.68	126.94	215.59
Overlap	Exclusives	0.05	31.93	31.15	41.03	58.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
combine_y_y_full Exclusive	156	153	PPIAL4C;RFPL2;AL162417.1
ad_gs Exclusive	21	21	
Overlap	4	4