Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
male_y_y_full Exclusive	ad_gs	7.08e-01	3.05e-01	1.67e-01	1.06e-02
ad_gs Exclusive	male_y_y_full	4.42e-01	4.76e-01	4.78e-02	5.45e-02
male_y_y_full Exclusive	ad_gs Exclusive	9.40e-01	5.49e-01	3.96e-01	1.68e-02
ad_gs Exclusive	male_y_y_full Exclusive	3.91e-01	6.15e-01	1.26e-01	1.54e-01
male_y_y_full Exclusive	Overlap	1.21e-01	6.77e-01	3.20e-02	3.55e-03
ad_gs Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	3.62e-03	1.33e-03	1.53e-15	2.43e-05



Evaluating how well male_y_y_full genes are linked to ad_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
male_y_y_full Exclusive	ad_gs	0.66	0.17	1.02	0.86	3.26
ad_gs Exclusive	male_y_y_full	0.56	1.62	1.16	1.59	2.60
male_y_y_full Exclusive	ad_gs Exclusive	0.64	-0.09	0.80	0.44	2.27
ad_gs Exclusive	male_y_y_full Exclusive	0.55	1.15	0.79	0.97	1.86
male_y_y_full Exclusive	Overlap	0.97	1.85	1.57	1.74	1.89
ad_gs Exclusive	Overlap	1.00	2.59	1.70	2.52	3.02
Overlap	Exclusives	0.63	3.79	3.99	2.43	5.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
male_y_y_full Exclusive	ad_gs	0.00	0.52	1.95	1.06	1.39
ad_gs Exclusive	male_y_y_full	0.01	3.41	2.00	3.43	3.87
male_y_y_full Exclusive	ad_gs Exclusive	0.00	0.27	1.38	0.50	1.51
ad_gs Exclusive	male_y_y_full Exclusive	0.01	0.85	0.29	0.77	0.43
male_y_y_full Exclusive	Overlap	0.00	0.93	1.14	1.65	3.98
ad_gs Exclusive	Overlap	0.05	151.05	178.00	111.23	120.37
Overlap	Exclusives	0.03	25.85	37.62	14.06	42.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
male_y_y_full Exclusive	103	103	
ad_gs Exclusive	23	23	
Overlap	2	2