Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
male_y_y_full Exclusive	ad_gs	7.21e-01	3.83e-01	2.01e-01	2.34e-02
ad_gs Exclusive	male_y_y_full	4.36e-01	5.85e-01	5.12e-02	8.64e-02
male_y_y_full Exclusive	ad_gs Exclusive	7.94e-01	6.43e-01	3.68e-01	1.89e-02
ad_gs Exclusive	male_y_y_full Exclusive	4.31e-01	5.89e-01	8.38e-02	1.56e-01
male_y_y_full Exclusive	Overlap	9.32e-02	6.27e-01	8.97e-03	8.97e-03
ad_gs Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	3.14e-03	1.32e-03	2.38e-16	3.11e-05



Evaluating how well male_y_y_full genes are linked to ad_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
male_y_y_full Exclusive	ad_gs	0.66	0.22	0.92	0.52	2.93
ad_gs Exclusive	male_y_y_full	0.56	1.44	0.90	1.75	2.43
male_y_y_full Exclusive	ad_gs Exclusive	0.64	-0.27	0.59	0.41	2.70
ad_gs Exclusive	male_y_y_full Exclusive	0.55	1.13	0.70	1.28	1.81
male_y_y_full Exclusive	Overlap	0.97	2.00	1.73	1.91	2.29
ad_gs Exclusive	Overlap	1.00	2.35	1.78	2.13	2.31
Overlap	Exclusives	0.63	4.03	4.35	2.55	4.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
male_y_y_full Exclusive	ad_gs	0.00	0.58	1.70	0.53	2.25
ad_gs Exclusive	male_y_y_full	0.01	2.82	1.81	3.50	1.34
male_y_y_full Exclusive	ad_gs Exclusive	0.00	0.10	1.32	0.91	0.71
ad_gs Exclusive	male_y_y_full Exclusive	0.01	0.94	0.25	0.94	0.60
male_y_y_full Exclusive	Overlap	0.00	1.49	1.31	6.84	0.74
ad_gs Exclusive	Overlap	0.05	125.43	137.29	142.24	350.00
Overlap	Exclusives	0.03	23.80	35.06	21.67	36.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
male_y_y_full Exclusive	103	103	
ad_gs Exclusive	23	23	
Overlap	2	2