Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Total_combsex_nonoverlap	Train_combsex_nonoverlap	8.79e-01	6.57e-01	8.23e-01	3.78e-01
Train_combsex_nonoverlap	Total_combsex_nonoverlap	4.32e-01	8.55e-01	3.14e-01	8.70e-01



Evaluating how well Total_combsex_nonoverlap genes are linked to Train_combsex_nonoverlap genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Total_combsex_nonoverlap	Train_combsex_nonoverlap	0.53	-0.15	0.31	-0.07	0.96
Train_combsex_nonoverlap	Total_combsex_nonoverlap	0.49	0.46	0.18	0.49	-0.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Total_combsex_nonoverlap	Train_combsex_nonoverlap	0.00	-0.13	0.31	0.02	0.09
Train_combsex_nonoverlap	Total_combsex_nonoverlap	0.00	-0.23	-0.55	-0.15	-0.60

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Total_combsex_nonoverlap	96	96	
Train_combsex_nonoverlap	71	70	AP000350.4