Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Total_female_nonoverlap	Train_female_nonoverlap	4.63e-01	2.70e-01	8.78e-01	4.71e-01
Train_female_nonoverlap	Total_female_nonoverlap	7.35e-01	5.56e-01	9.02e-01	9.36e-01



Evaluating how well Total_female_nonoverlap genes are linked to Train_female_nonoverlap genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Total_female_nonoverlap	Train_female_nonoverlap	0.54	1.18	1.58	1.22	1.00
Train_female_nonoverlap	Total_female_nonoverlap	0.50	0.74	0.86	0.68	0.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Total_female_nonoverlap	Train_female_nonoverlap	0.00	0.38	0.55	0.31	0.83
Train_female_nonoverlap	Total_female_nonoverlap	0.00	0.58	0.59	0.04	0.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Total_female_nonoverlap	77	77	
Train_female_nonoverlap	58	58