Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Nonoverlap_total_male	Nonoverlap_train_male	9.50e-01	9.71e-01	9.00e-01	9.68e-01
Nonoverlap_train_male	Nonoverlap_total_male	3.75e-01	6.45e-01	4.99e-01	1.85e-01



Evaluating how well Nonoverlap_total_male genes are linked to Nonoverlap_train_male genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Nonoverlap_total_male	Nonoverlap_train_male	0.49	-0.47	0.01	-0.13	-0.26
Nonoverlap_train_male	Nonoverlap_total_male	0.53	0.34	0.04	0.14	1.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Nonoverlap_total_male	Nonoverlap_train_male	0.00	-0.20	-0.22	0.12	-0.15
Nonoverlap_train_male	Nonoverlap_total_male	0.00	-0.17	-0.21	-0.21	0.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Nonoverlap_total_male	82	82	
Nonoverlap_train_male	61	61