Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
NIAGADS 6K male Exclusive	25-GS	6.25e-01	6.83e-01	5.90e-01	7.48e-02
25-GS Exclusive	NIAGADS 6K male	9.25e-01	7.97e-01	2.76e-01	4.96e-01
NIAGADS 6K male Exclusive	25-GS Exclusive	5.30e-01	6.37e-01	9.03e-01	1.69e-01
25-GS Exclusive	NIAGADS 6K male Exclusive	8.40e-01	9.66e-01	4.82e-01	7.14e-01
NIAGADS 6K male Exclusive	Overlap	6.77e-01	4.21e-01	5.37e-01	6.93e-02
25-GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	2.77e-03	2.14e-03	3.56e-12	1.50e-04



Evaluating how well NIAGADS 6K male genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
NIAGADS 6K male Exclusive	25-GS	0.61	-0.45	-0.13	-0.12	1.64
25-GS Exclusive	NIAGADS 6K male	0.54	1.05	0.69	1.16	1.27
NIAGADS 6K male Exclusive	25-GS Exclusive	0.58	-0.73	0.05	-0.42	1.23
25-GS Exclusive	NIAGADS 6K male Exclusive	0.53	0.72	0.24	0.39	0.73
NIAGADS 6K male Exclusive	Overlap	0.86	1.30	0.91	1.09	2.11
25-GS Exclusive	Overlap	1.00	2.15	1.86	2.35	2.43
Overlap	Exclusives	0.63	3.31	3.79	2.37	4.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
NIAGADS 6K male Exclusive	25-GS	0.00	-0.61	-0.51	-0.24	-0.09
25-GS Exclusive	NIAGADS 6K male	0.01	2.43	2.17	2.70	0.57
NIAGADS 6K male Exclusive	25-GS Exclusive	0.00	-0.78	-0.33	-0.43	0.08
25-GS Exclusive	NIAGADS 6K male Exclusive	0.00	-0.20	-0.59	-0.34	-0.17
NIAGADS 6K male Exclusive	Overlap	0.00	0.12	-0.17	0.00	1.02
25-GS Exclusive	Overlap	0.05	123.70	144.95	156.24	408.98
Overlap	Exclusives	0.03	35.44	37.67	14.63	18.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
NIAGADS 6K male Exclusive	72	71	
25-GS Exclusive	23	22	HLA -DRB1
Overlap	2	2