Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) ad genes Exclusive pd genes 9.29e-01 5.97e-01 9.51e-01 7.83e-01 pd genes Exclusive ad genes 3.87e-01 6.54e-01 2.60e-01 6.43e-01 ad genes Exclusive pd genes Exclusive 9.41e-01 5.29e-01 8.39e-01 4.60e-01 pd genes Exclusive ad genes Exclusive 4.27e-01 6.01e-01 3.07e-01 7.35e-01 ad genes Exclusive Overlap 2.52e-01 3.34e-01 1.41e-01 4.71e-02 pd genes Exclusive Overlap 8.49e-01 3.01e-01 9.52e-01 1.58e-01 Overlap Exclusives 3.49e-01 7.61e-01 4.19e-25 9.01e-01 Evaluating how well ad genes genes are linked to pd genes genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) ad genes Exclusive pd genes 0.49 0.02 -1.07 -0.46 -0.62 pd genes Exclusive ad genes 0.52 -1.07 -0.58 -0.80 0.85 ad genes Exclusive pd genes Exclusive 0.48 -0.21 -1.36 -0.75 -1.15 pd genes Exclusive ad genes Exclusive 0.51 -0.85 -0.60 -0.81 0.24 ad genes Exclusive Overlap 0.83 1.05 0.23 1.41 2.09 pd genes Exclusive Overlap 0.77 0.33 1.19 0.47 1.70 Overlap Exclusives 0.50 -0.63 -0.26 -0.13 0.27 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) ad genes Exclusive pd genes 0.01 -0.31 -1.08 -0.65 -0.80 pd genes Exclusive ad genes 0.01 -0.79 -0.31 -0.73 0.01 ad genes Exclusive pd genes Exclusive 0.01 -0.41 -1.07 -0.82 -1.34 pd genes Exclusive ad genes Exclusive 0.01 -1.11 -0.32 -0.71 -0.22 ad genes Exclusive Overlap 0.00 -0.00 -0.81 0.32 0.06 pd genes Exclusive Overlap 0.00 -0.42 0.80 -0.38 -0.06 Overlap Exclusives 0.01 -0.03 0.55 0.45 0.60 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes ad genes Exclusive 118 117 RFPL2 pd genes Exclusive 155 153 ARLĀ 11.00;ERNĀ 2.00 Overlap 4 4