Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_sigma-diff Exclusive	32-GS	3.42e-08	9.19e-09	1.11e-10	1.90e-11
32-GS Exclusive	122_sigma-diff	1.08e-01	1.65e-01	8.16e-03	4.90e-03
122_sigma-diff Exclusive	32-GS Exclusive	4.02e-06	1.94e-07	2.07e-09	3.99e-09
32-GS Exclusive	122_sigma-diff Exclusive	4.21e-01	3.56e-01	6.46e-02	1.80e-02
122_sigma-diff Exclusive	Overlap	6.04e-07	1.19e-02	6.04e-07	1.28e-07
32-GS Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	9.14e-09
Overlap	Exclusives	1.47e-05	6.17e-05	8.11e-15	1.02e-06



Evaluating how well 122_sigma-diff genes are linked to 32-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff Exclusive	32-GS	0.87	4.41	7.16	3.91	6.36
32-GS Exclusive	122_sigma-diff	0.60	3.41	2.14	2.89	3.72
122_sigma-diff Exclusive	32-GS Exclusive	0.85	3.16	6.25	4.22	5.30
32-GS Exclusive	122_sigma-diff Exclusive	0.58	2.79	1.75	2.35	2.59
122_sigma-diff Exclusive	Overlap	0.99	2.73	2.81	2.78	3.45
32-GS Exclusive	Overlap	1.00	2.62	3.74	2.77	3.26
Overlap	Exclusives	0.64	4.19	5.02	2.97	5.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff Exclusive	32-GS	0.02	25.37	29.65	20.05	26.31
32-GS Exclusive	122_sigma-diff	0.03	32.72	24.27	25.14	33.25
122_sigma-diff Exclusive	32-GS Exclusive	0.01	10.88	38.65	22.01	23.00
32-GS Exclusive	122_sigma-diff Exclusive	0.02	9.47	12.87	7.69	14.69
122_sigma-diff Exclusive	Overlap	0.02	27.42	21.75	11.20	57.77
32-GS Exclusive	Overlap	0.10	169.97	131.36	191.51	131.40
Overlap	Exclusives	0.09	67.07	126.91	51.41	131.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_sigma-diff Exclusive	114	113	RFPL2
32-GS Exclusive	26	25	MS4A
Overlap	5	4