Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_sigma-diff Exclusive	77-GS	1.11e-05	1.06e-05	2.17e-08	6.20e-11
77-GS Exclusive	122_sigma-diff	2.95e-02	1.07e-01	4.06e-04	2.82e-03
122_sigma-diff Exclusive	77-GS Exclusive	2.10e-04	9.69e-05	1.50e-07	1.37e-08
77-GS Exclusive	122_sigma-diff Exclusive	2.49e-01	2.14e-01	6.94e-03	1.77e-02
122_sigma-diff Exclusive	Overlap	6.53e-04	1.37e-03	4.43e-05	9.11e-06
77-GS Exclusive	Overlap	2.81e-06	7.20e-04	4.61e-08	5.59e-06
Overlap	Exclusives	1.64e-09	7.84e-10	1.33e-20	3.46e-11



Evaluating how well 122_sigma-diff genes are linked to 77-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff Exclusive	77-GS	0.73	3.34	5.74	3.42	7.49
77-GS Exclusive	122_sigma-diff	0.60	2.68	2.80	3.01	3.74
122_sigma-diff Exclusive	77-GS Exclusive	0.71	2.94	5.15	3.31	6.60
77-GS Exclusive	122_sigma-diff Exclusive	0.58	2.13	1.96	2.21	2.95
122_sigma-diff Exclusive	Overlap	0.98	2.71	3.41	3.17	3.60
77-GS Exclusive	Overlap	0.99	3.46	3.68	3.57	3.64
Overlap	Exclusives	0.67	5.77	7.12	3.44	7.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff Exclusive	77-GS	0.02	11.82	19.65	15.32	32.44
77-GS Exclusive	122_sigma-diff	0.03	37.00	33.01	37.24	40.95
122_sigma-diff Exclusive	77-GS Exclusive	0.01	7.22	16.67	14.60	17.39
77-GS Exclusive	122_sigma-diff Exclusive	0.02	12.68	15.75	18.89	19.48
122_sigma-diff Exclusive	Overlap	0.01	21.32	29.53	22.14	14.54
77-GS Exclusive	Overlap	0.12	97.16	196.22	401.35	429.61
Overlap	Exclusives	0.10	76.80	105.39	37.28	112.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_sigma-diff Exclusive	113	112	RFPL2
77-GS Exclusive	71	67	MS4A;TNSF12;IGH;TNSF13
Overlap	6	5