Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_sigma-diff Exclusive	46-tier2-GS	1.33e-02	9.20e-03	7.93e-04	1.74e-04
46-tier2-GS Exclusive	122_sigma-diff	2.05e-01	1.33e-01	4.66e-04	1.16e-02
122_sigma-diff Exclusive	46-tier2-GS Exclusive	4.85e-02	1.65e-02	9.52e-04	1.72e-04
46-tier2-GS Exclusive	122_sigma-diff Exclusive	1.65e-01	1.38e-01	9.32e-04	8.23e-03
122_sigma-diff Exclusive	Overlap	5.94e-02	9.90e-02	1.98e-02	9.90e-02
46-tier2-GS Exclusive	Overlap	2.77e-01	4.16e-01	9.90e-02	3.17e-01
Overlap	Exclusives	9.83e-03	2.92e-02	2.50e-08	6.44e-06



Evaluating how well 122_sigma-diff genes are linked to 46-tier2-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff Exclusive	46-tier2-GS	0.68	1.97	2.47	2.52	3.67
46-tier2-GS Exclusive	122_sigma-diff	0.59	2.44	2.46	2.51	3.13
122_sigma-diff Exclusive	46-tier2-GS Exclusive	0.68	1.63	2.53	2.12	3.96
46-tier2-GS Exclusive	122_sigma-diff Exclusive	0.59	2.53	2.34	2.57	3.29
122_sigma-diff Exclusive	Overlap	0.96	1.75	1.40	1.80	1.45
46-tier2-GS Exclusive	Overlap	0.84	1.37	1.06	1.41	1.11
Overlap	Exclusives	0.61	2.48	2.73	2.34	4.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff Exclusive	46-tier2-GS	0.01	5.22	10.08	8.05	1.69
46-tier2-GS Exclusive	122_sigma-diff	0.01	8.83	6.91	5.40	8.26
122_sigma-diff Exclusive	46-tier2-GS Exclusive	0.01	3.41	10.56	8.18	2.44
46-tier2-GS Exclusive	122_sigma-diff Exclusive	0.01	8.22	6.46	8.99	10.06
122_sigma-diff Exclusive	Overlap	0.00	3.27	1.10	3.91	1.11
46-tier2-GS Exclusive	Overlap	0.00	0.68	0.03	0.75	-0.07
Overlap	Exclusives	0.01	3.25	3.67	2.82	3.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_sigma-diff Exclusive	118	116	;RFPL2
46-tier2-GS Exclusive	45	42	TNSF13;TNSF12;IGH
Overlap	1	1