Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_sigma-diff	25-tier3-GS	8.02e-01	4.14e-01	4.46e-01	5.78e-01
25-tier3-GS	122_sigma-diff	1.76e-01	4.50e-01	1.08e-01	2.55e-02



Evaluating how well 122_sigma-diff genes are linked to 25-tier3-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff	25-tier3-GS	0.56	0.05	0.57	0.56	1.23
25-tier3-GS	122_sigma-diff	0.57	2.16	1.37	1.61	2.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff	25-tier3-GS	0.00	0.13	1.17	0.62	0.60
25-tier3-GS	122_sigma-diff	0.01	0.57	0.51	0.60	0.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_sigma-diff	118	117	RFPL2
25-tier3-GS	23	21	APT8B4;AC074212.3