Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
82_male_sigma-diff Exclusive	31-GS	1.35e-07	2.84e-07	1.98e-08	3.29e-09
31-GS Exclusive	82_male_sigma-diff	6.53e-01	3.23e-01	8.28e-02	8.42e-02
82_male_sigma-diff Exclusive	31-GS Exclusive	5.35e-06	2.12e-06	5.82e-07	1.04e-07
31-GS Exclusive	82_male_sigma-diff Exclusive	8.37e-01	5.22e-01	1.44e-01	1.67e-01
82_male_sigma-diff Exclusive	Overlap	3.68e-03	8.22e-02	2.85e-03	1.98e-04
31-GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	9.58e-06	7.40e-06	9.56e-18	1.93e-07



Evaluating how well 82_male_sigma-diff genes are linked to 31-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma-diff Exclusive	31-GS	0.82	4.02	5.63	3.08	5.45
31-GS Exclusive	82_male_sigma-diff	0.56	1.57	1.19	1.86	1.76
82_male_sigma-diff Exclusive	31-GS Exclusive	0.80	3.55	4.56	2.79	5.22
31-GS Exclusive	82_male_sigma-diff Exclusive	0.54	1.09	0.77	1.37	1.16
82_male_sigma-diff Exclusive	Overlap	0.97	2.94	2.31	2.19	3.03
31-GS Exclusive	Overlap	1.00	3.13	2.57	2.88	2.95
Overlap	Exclusives	0.66	3.58	5.90	3.55	5.38

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma-diff Exclusive	31-GS	0.01	10.93	12.64	7.67	9.74
31-GS Exclusive	82_male_sigma-diff	0.03	13.68	37.35	24.46	37.50
82_male_sigma-diff Exclusive	31-GS Exclusive	0.01	7.79	8.14	3.19	4.32
31-GS Exclusive	82_male_sigma-diff Exclusive	0.02	18.71	19.94	9.45	25.22
82_male_sigma-diff Exclusive	Overlap	0.00	9.99	8.85	5.26	0.20
31-GS Exclusive	Overlap	0.10	146.19	105.36	217.23	116.95
Overlap	Exclusives	0.09	73.37	153.76	105.69	147.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
82_male_sigma-diff Exclusive	77	77	
31-GS Exclusive	27	26	MS4A
Overlap	4	3