Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
69_female_sigma-diff Exclusive	31-GS	3.38e-06	1.46e-06	8.22e-08	8.22e-08
31-GS Exclusive	69_female_sigma-diff	1.90e-01	7.13e-01	3.78e-01	5.92e-01
69_female_sigma-diff Exclusive	31-GS Exclusive	2.37e-05	1.79e-06	3.30e-06	8.34e-07
31-GS Exclusive	69_female_sigma-diff Exclusive	1.67e-01	8.32e-01	6.86e-01	9.31e-01
69_female_sigma-diff Exclusive	Overlap	3.46e-02	6.10e-01	1.87e-02	1.18e-02
31-GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	2.32e-05	4.18e-06	6.19e-15	3.01e-07



Evaluating how well 69_female_sigma-diff genes are linked to 31-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma-diff Exclusive	31-GS	0.82	2.87	5.56	4.19	5.91
31-GS Exclusive	69_female_sigma-diff	0.52	-0.11	-0.14	0.35	0.54
69_female_sigma-diff Exclusive	31-GS Exclusive	0.81	2.42	6.10	3.11	6.41
31-GS Exclusive	69_female_sigma-diff Exclusive	0.50	-0.30	-0.59	-0.09	0.07
69_female_sigma-diff Exclusive	Overlap	0.97	1.57	1.59	1.95	2.19
31-GS Exclusive	Overlap	1.00	2.31	2.03	2.61	2.79
Overlap	Exclusives	0.67	6.19	6.50	3.42	6.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma-diff Exclusive	31-GS	0.01	6.66	14.90	13.73	7.72
31-GS Exclusive	69_female_sigma-diff	0.02	35.17	25.68	27.47	36.80
69_female_sigma-diff Exclusive	31-GS Exclusive	0.01	3.21	16.58	1.18	6.77
31-GS Exclusive	69_female_sigma-diff Exclusive	0.02	31.86	32.94	16.86	27.15
69_female_sigma-diff Exclusive	Overlap	0.00	3.79	1.70	2.95	2.76
31-GS Exclusive	Overlap	0.05	130.33	241.04	337.84	99.58
Overlap	Exclusives	0.05	18.57	94.51	37.14	92.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
69_female_sigma-diff Exclusive	65	63	RAB6D;RFPL2
31-GS Exclusive	28	27	MS4A
Overlap	3	2