Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
69_female_sigma-diff Exclusive	31-GS	6.53e-07	1.59e-06	1.23e-07	1.04e-07
31-GS Exclusive	69_female_sigma-diff	2.93e-01	8.02e-01	3.45e-01	6.11e-01
69_female_sigma-diff Exclusive	31-GS Exclusive	1.36e-05	3.16e-06	2.00e-06	4.68e-07
31-GS Exclusive	69_female_sigma-diff Exclusive	1.20e-01	9.49e-01	6.90e-01	9.51e-01
69_female_sigma-diff Exclusive	Overlap	1.68e-02	5.74e-01	2.49e-02	3.55e-03
31-GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.69e-05	3.91e-06	7.90e-18	2.51e-07



Evaluating how well 69_female_sigma-diff genes are linked to 31-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma-diff Exclusive	31-GS	0.82	2.74	6.18	3.88	6.19
31-GS Exclusive	69_female_sigma-diff	0.52	0.06	-0.39	0.24	0.46
69_female_sigma-diff Exclusive	31-GS Exclusive	0.81	2.75	4.91	3.34	5.66
31-GS Exclusive	69_female_sigma-diff Exclusive	0.50	-0.44	-0.26	-0.06	0.04
69_female_sigma-diff Exclusive	Overlap	0.97	1.55	1.56	2.05	2.43
31-GS Exclusive	Overlap	1.00	2.19	2.07	2.32	2.38
Overlap	Exclusives	0.67	5.49	6.10	3.86	6.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma-diff Exclusive	31-GS	0.01	6.85	15.43	11.35	10.75
31-GS Exclusive	69_female_sigma-diff	0.02	41.94	17.85	35.81	43.20
69_female_sigma-diff Exclusive	31-GS Exclusive	0.01	6.70	15.08	8.49	1.30
31-GS Exclusive	69_female_sigma-diff Exclusive	0.02	18.06	20.15	9.80	19.51
69_female_sigma-diff Exclusive	Overlap	0.00	4.24	2.42	3.80	6.08
31-GS Exclusive	Overlap	0.05	96.00	88.29	225.58	99.30
Overlap	Exclusives	0.05	61.07	90.86	37.10	41.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
69_female_sigma-diff Exclusive	65	63	RFPL2;RAB6D
31-GS Exclusive	28	27	MS4A
Overlap	3	2