Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GS-Juan Exclusive	UKB-PD_combinedsex_mudiff	3.89e-03	7.94e-01	3.00e-25	6.50e-01
UKB-PD_combinedsex_mudiff Exclusive	GS-Juan	7.14e-01	9.08e-01	8.98e-01	8.14e-03
GS-Juan Exclusive	UKB-PD_combinedsex_mudiff Exclusive	3.29e-03	8.36e-01	2.60e-25	4.53e-01
UKB-PD_combinedsex_mudiff Exclusive	GS-Juan Exclusive	9.11e-01	8.82e-01	9.87e-01	1.17e-02
GS-Juan Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
UKB-PD_combinedsex_mudiff Exclusive	Overlap	9.90e-01	6.53e-01	8.71e-01	4.16e-01
Overlap	Exclusives	4.21e-04	9.51e-02	7.68e-20	4.53e-02



Evaluating how well GS-Juan genes are linked to UKB-PD_combinedsex_mudiff genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS-Juan Exclusive	UKB-PD_combinedsex_mudiff	0.50	-0.22	-0.13	0.20	0.10
UKB-PD_combinedsex_mudiff Exclusive	GS-Juan	0.76	-0.38	-0.18	-0.18	3.34
GS-Juan Exclusive	UKB-PD_combinedsex_mudiff Exclusive	0.50	-0.46	-0.19	0.05	-0.03
UKB-PD_combinedsex_mudiff Exclusive	GS-Juan Exclusive	0.75	-0.39	-0.28	-0.03	3.12
GS-Juan Exclusive	Overlap	1.00	2.48	1.71	1.96	2.02
UKB-PD_combinedsex_mudiff Exclusive	Overlap	0.80	0.13	0.02	0.17	0.95
Overlap	Exclusives	0.53	3.12	0.95	1.19	2.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS-Juan Exclusive	UKB-PD_combinedsex_mudiff	0.01	0.11	-0.18	0.18	-0.03
UKB-PD_combinedsex_mudiff Exclusive	GS-Juan	0.00	-0.39	-1.37	-0.33	5.25
GS-Juan Exclusive	UKB-PD_combinedsex_mudiff Exclusive	0.01	-0.44	-0.36	-0.37	-0.46
UKB-PD_combinedsex_mudiff Exclusive	GS-Juan Exclusive	0.00	-0.33	-1.09	-0.13	2.53
GS-Juan Exclusive	Overlap	0.02	127.93	117.10	18.26	66.21
UKB-PD_combinedsex_mudiff Exclusive	Overlap	0.00	-0.38	-0.66	-0.34	0.08
Overlap	Exclusives	0.01	6.93	2.62	2.84	3.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GS-Juan Exclusive	11	11	
UKB-PD_combinedsex_mudiff Exclusive	204	202	KDM5D;C17orf113
Overlap	1	1