Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GS-Juan Exclusive	UKB-PD_combinedsex_mudiff_half	2.09e-02	5.40e-01	2.71e-08	8.20e-01
UKB-PD_combinedsex_mudiff_half Exclusive	GS-Juan	3.43e-01	5.01e-01	5.62e-01	1.85e-02
GS-Juan Exclusive	UKB-PD_combinedsex_mudiff_half Exclusive	1.72e-02	5.42e-01	2.85e-08	6.20e-01
UKB-PD_combinedsex_mudiff_half Exclusive	GS-Juan Exclusive	6.31e-01	6.52e-01	7.86e-01	1.24e-02
GS-Juan Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
UKB-PD_combinedsex_mudiff_half Exclusive	Overlap	7.33e-01	8.51e-01	7.33e-01	7.33e-01
Overlap	Exclusives	7.25e-02	1.96e-01	1.20e-11	6.63e-02



Evaluating how well GS-Juan genes are linked to UKB-PD_combinedsex_mudiff_half genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS-Juan Exclusive	UKB-PD_combinedsex_mudiff_half	0.48	-1.45	-1.43	-0.44	-0.44
UKB-PD_combinedsex_mudiff_half Exclusive	GS-Juan	0.71	-0.68	-0.12	-0.24	2.31
GS-Juan Exclusive	UKB-PD_combinedsex_mudiff_half Exclusive	0.48	-1.72	-1.13	-0.55	-0.55
UKB-PD_combinedsex_mudiff_half Exclusive	GS-Juan Exclusive	0.72	-0.47	-0.10	-0.19	2.54
GS-Juan Exclusive	Overlap	1.00	2.07	1.93	2.40	1.81
UKB-PD_combinedsex_mudiff_half Exclusive	Overlap	0.60	-0.47	-0.12	-0.40	0.44
Overlap	Exclusives	0.55	2.01	0.84	0.82	1.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS-Juan Exclusive	UKB-PD_combinedsex_mudiff_half	0.00	0.72	0.44	0.91	0.66
UKB-PD_combinedsex_mudiff_half Exclusive	GS-Juan	0.00	-0.76	-1.46	-0.57	0.14
GS-Juan Exclusive	UKB-PD_combinedsex_mudiff_half Exclusive	0.00	-0.55	-0.29	-0.23	-0.33
UKB-PD_combinedsex_mudiff_half Exclusive	GS-Juan Exclusive	0.00	-0.52	-1.27	-0.38	1.07
GS-Juan Exclusive	Overlap	0.02	159.68	138.20	124.85	39.94
UKB-PD_combinedsex_mudiff_half Exclusive	Overlap	0.00	-0.21	-0.47	-0.43	-0.20
Overlap	Exclusives	0.01	6.52	4.64	2.22	3.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GS-Juan Exclusive	11	11	
UKB-PD_combinedsex_mudiff_half Exclusive	76	75	KDM5D
Overlap	1	1